Acetaminophen Metabolite Interferes in Analysis for Amino

نویسندگان

  • Zhor El-Mokhefi
  • Joseph A. Duvivier
  • Guy G. Plomteux
  • Jacques E. Gielen
چکیده

protein-X in cholestasis. Clin Chim Acta 67, 269-279 (1976). 7. Crofton PM, Smith AF. Alkaline phosphatase of high and low molecular mass in human serum and bile: A comparative study of kinetic properties. Clin Chem 26, 451-456 (1980). 8. Plomteux G, Reginster N. Mesure des fractions hepatique, intestinale et osseuse des phosphatases alcalines du serum. Ann Biol Clin 38, 215-222 (1980). 9. Lean HW, Diaz D, Szakaly M. A study of alkaline phosphatase isoenzyme electrophoresis on cellulose acetate compared with agar, agarose and acrylamide in the presence or absence of Thton X-100. Clin Chim Acta 91, 147-152 (1979). 10. Crofton PM. Biochemistry of alkaline phosphatase isoenzymes.Crit Rev Clin Lab Sci 16, 161-194 (1982). 11. Lehmann FG. Immunological relationshipbetween human placental and intestinal alkaline phosphatase. Clin Chim Acta 65, 257-269 (1975). 12. Wicks R, Victor J, Usetagui-Gomez M. Immunochemical characterization of a fastmigrating isoenzyme of alkaline phosphataae. Clin Chem 28, 1600 (1982). Abstract.

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Covalent binding of acetaminophen to N-10-formyltetrahydrofolate dehydrogenase in mice.

The analgesic acetaminophen is frequently used as a model chemical to study hepatotoxicity; however, the critical mechanisms by which it produces toxicity within the cell are unknown. It has been postulated that covalent binding of a toxic metabolite to crucial proteins may inhibit vital cellular functions and may be responsible for, or contribute to, the hepatotoxicity. To further understand t...

متن کامل

Survey of potential diagnostic metabolite markers in serum of the rat model of Alzheimer’s disease using nuclear magnatic resonance (1H-NMR) technique

Introduction: The high prevalence of Alzheimerchr('39')s disease (AD) in todaychr('39')s societies indicates an urgent need for the development of methods that will help the early diagnosis of the disease. In this study, using proton nuclear magnetic resonance spectrometry (1H-NMR) metabolomics, identification of altered and distinct metabolites in serum of the rat model of AD was performed com...

متن کامل

Acetaminophen elimination half-life in humans is unaffected by short-term consumption of sulfur amino acid-free diet.

Sulfation and glutathione (GSH) conjugation are important pathways for elimination of acetaminophen (APAP). Previous studies in rodents show that limitation of dietary sulfur amino acids (SAAs) reduces biosynthesis of 3'-phosphoadenosine-5'-phosphosulfate, the precursor for sulfation, and GSH, the precursor for the mercapturatic acid pathway. The amount of SAA needed for the metabolism of two d...

متن کامل

Metabolite kinetics: formation of acetaminophen from deuterated and nondeuterated phenacetin and acetanilide on acetaminophen sulfation kinetics in the perfused rat liver preparation.

The role of hepatic intrinsic clearance for metabolite formation from various precursors on subsequent metabolite elimination was was investigated in the once-through perfused rat liver preparation. Two pairs of acetaminophen precursors: [14C] phenacetin-d5 and [3H] phenacetin-do, [14C] acetanilide and [3H] phenacetin were delivered by constant flow (10 ml/min/liver) either by normal or retrogr...

متن کامل

Mumijo Protection gainst Acetaminophen-Induced Acute Hepatic Injury: Role of Oxidative Stress

Background: A majority of people widely use acetaminophen as a sedative. Overusing the drug for prolonged periods of time can lead to acute liver damage. Mumijo, as a strong antioxidant and anti-inflammatory drug, could possibly reduce some of the acetaminophen-induced side effects on the liver. Thus, the aim of this study is to evaluate the effect of Mumijo on the liver damage...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2004